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Vitamin B12 deficiency, opioid use disorder or bacterial infection)

You might wonder how a pill works if you lack intrinsic factor: at very high oral doses, a small amount of B12 can be absorbed directly through the gut wall via passive diffusion, bypassing the need for intrinsic factor entirely [1] [3]

Symptoms of B12 deficiency include exhaustion no matter how much you sleep, muscle weakness and frequent cramping, constipation, loss of appetite and unexplained weight loss, numbness or tingling in the hands and feet, depression, and problems with memory and focus

Some patients report that: For patients experiencing more pain, medications like acetaminophen (Tylenol) or ibuprofen (Advil) may help with pain relief and inflammation

Vitamin B12 shots require expert formulation and medical oversight, making it essential to choose a trusted clinic

Nature Chemical Biology 9(5):300-306