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identified six serum metabolites that could specifically predict the need for imaging and reported that reductions in 2-aminobutyric acid (generated in the biosynthesis of the BCAA isoleucine) and increases in the ketone body acetoacetic acid corresponded to positive CT findings [41]

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When -catenin deletion instead occurred after the initiation of hair cell differentiation (after the onset of early hair cell markers Atoh1 and Gfi1 ), using a hair cell specific Cre driver, hair cell maturation appeared unaffected, suggesting that Wnt/-catenin signaling is required for proliferation of prosensory cells and for differentiation of hair cells but not for their subsequent maintenance

Human genome-microbiome interaction: metagenomics frontiers for the aetiopathology of autoimmune diseases