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10.22270/jddt.v12i2-s.5280 [DOI] [Google Scholar] Ramya S., Loganathan T., Chandran M., Priyanka R., Kavipriya K., Pushpalatha GLGL, et al

Immunochem (2019) 40:12338

In addition, the alteration of GAPDH and PK in AD was further described by an immunoproteomic approach that demonstrated the presence in the CSF of autoantibodies against these enzymes (397), consistent with the notion that proteins undergoing ox-PTMs become toxic to neurons, which induce clearance systems and immune responses

Human clinical evidence is more limited and often comes from older Russian studies with smaller sample sizes

Conflict of Interest The authors do not have any conflict of interest

Low-quality evidence from another trial that compared the effect of ALCAR (1.5 g/day) with that of methylcobalamin (1.5 mg/day) for 24 weeks suggested no difference between treatments regarding the extent of functional disability (using the Neuropathy Disability Scale) or measures of symptom quality and severity (using the Neuropathy Symptom Scale) (89)