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The kynurenine pathway can lead to an increase in quinolinic acid, which is a neurotoxin.[ref] Related article: More on tryptophan, kynurenine, inflammation, and genetics Higher BH4 and increased pain: trade-offs Low levels of tetrahydrobiopterin have been the subject of much research, with many studies showing the benefits of increasing BH4 for cognitive and cardiac function

Although studies specifically targeting SCA3 are limited, crocins inhibition of ceramide pathways and enhancement of the glutathione system suggest potential efficacy against polyglutamine-related neuronal degeneration

Janeiro MH, Ramirez MJ, Milagro FI, Martinez JA, Solas M (2018) Implication of Trimethylamine N-Oxide (TMAO) in disease: potential biomarker or new therapeutic target

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10.1158/1078-0432.CCR-14-2810 79 PilchJ.KowalikP.KowalczykA.BujakP.KasprzakA.PaluszkiewiczE.et al (2022)

JAMA 301, 6373,2009