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Vitamin B12 deficiency can occur due to dietary restrictions (vegetarian or vegan diets), absorption issues (pernicious anemia or gut disorders like celiac disease or Crohns disease), age-related changes in elderly patients, or long-term use of certain medicines

Other reported effects include breast tenderness or enlargement in a small percentage of male users, mood changes, and a rare association with high-grade prostate cancer in some analyses (this finding remains debated in the literature)

In addition, the feasibility of PRIT as a CD38-based therapy was confirmed in murine models with excellent tumor-to-normal organ ratios of absorbed dose [129]

These dosing conventions emerged from practitioner experience and extrapolation from preclinical models

*Correspondence: Qiao Hong, [email protected] This article was submitted to Gastrointestinal Cancers: Colorectal Cancer, a section of the journal Frontiers in Oncology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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