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Characterizing the mechanism of action for mRNA therapeutics for the treatment of propionic acidemia, methylmalonic acidemia, and phenylketonuria

Whether GSH regulates cell adhesion through extracellular action rather than increased intracellular contents was supported by the extremely fast cell adhesion force reduction observed in real-time experiments

C5L2 ligand binding induces their internalization and degradation, which decreases their extracellular expression level, which is a step to decrease the generation of profound or tissue-damaging complement-mediated inflammatory immune response (241)

These data are protected by a confidentiality agreement with the study sponsor, Zambon S.p.A., Italy, due to their ethically and commercially sensitive nature

In NSCLC, the predominant subtype of lung cancer, mutations in apoptotic regulators, such as TP53, allow tumors to escape conventional therapies (Canale et al