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When the vitreous gel is removed surgically, it is replaced by fluid, which does not provide a comparable level of inhibition of diffusion

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However, extensive clinical trials are needed for validation

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These mechanisms are highly interconnected: A deposition can trigger neuroinflammation and oxidative stress, tau pathology contributes to synaptic and mitochondrial dysfunction, and genetic risk factors further influence immune and endosomallysosomal pathways

Excellent laccase-like activity of melamine modified Cu-NH 2 -BDC and selective sensing analyses toward phenols and amines