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IL-6, a pivotal pro-inflammatory cytokine, exhibits a positive correlation with an elevated risk of cardiovascular mortality and the incidence of major adverse cardiovascular events (66)

91 Resting-state FDG-PET analyses revealed marked hemispheric asymmetry in the metabolic activity of the primary auditory cortex, with tinnitus patients showing significantly greater left-sided resting activity than both the contralateral hemisphere and healthy controls

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Notably, during NP safety assessments, high doses [18 mg/(kgd)] or Ces2h deficiency could induce oxidative stress and toxicity