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However, as we did not directly measure ATP levels, further investigation is needed to determine the precise downstream mechanisms involved

ATP6AP1 associates with the V 0 sector of lysosomal v-ATPase, and its loss impairs lysosomal acidification v-ATPases are present in multiple cellular locations as proton pumps, such as the plasma membrane, Golgi-derived and secretory vesicles, endosomes and lysosomes 27

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The fact that we did not observe an antiviral effect in the lower respiratory tract underscores the need of further treatment optimization before its potential evaluation in humans

Thymol improves barrier function and attenuates inflammatory responses in porcine intestinal epithelial cells during lipopolysaccharide (LPS)-induced inflammation

Longer follow up and larger patient populations are needed to define the role of GC+D treatment for BTC outside of clinical trials