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Glutathione metabolism modulates the sensitivity to BH3 mimetics Glutathione S-transferases (GST) are detoxifying enzymes that protect mammalian macromolecules from reactive electrophilic substances using glutathione (GSH) as a xenobiotic acceptor 49

Written by Kerri Lewis, Co-founder | Medically reviewed by Nurse Natalia Ostrowska RGN and INP | The Skin to Love Clinic, St

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Table 1 Summary of pilot studies on vitamins C and E, NAC, CoQ10, and melatonin discussed in this article

Pre-clinical vs Clinical Translation Challenges Concentrations that produce robust in-vitro fibroblast responses may not translate predictably to in-vivo or human contexts