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Since it has emerged as a key mediator in sepsis and contributes to the high lethality of sepsis, HMGB1-targeting strategies may be effective to treat sepsis (39)

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IGF-I may be beneficial in the mild types of motor neuron diseases since IGF-I is a pro-survival factor for motor neuron-derived cells[79]

Supplementation of butyrate (all Sigma-Aldrich, Germany) was done in the drinking water at a final concentration of 150 mM and changed every 3 days and control mice received pH and sodium-matched water