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Genomic assessment of a multikinase inhibitor, sorafenib, in a rodent model of pulmonary hypertension

doi: 10.1186/s12866-021-02125-1 119 ZhaoZ.NingJ.BaoX

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In vivo studies Experimental work Animals were maintained under specific-pathogen-free conditions and in compliance with the Northern Ireland Department of Health (under PPL 2874 and 2960) regulations with approval from the QUB Animal Welfare and Ethical Review Body

Targeting PI3K/Akt signaling pathway In pre-clinical studies, phosphatase and tension homolog is acknowledged as a negative regulator of the PI3K/Akt pathway in PH treatment 190 (Table 1)