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The focus is on SIRT1s roles in hepatic lipid metabolism reprogramming, insulin signaling, oxidative stress control, and intrahepatic immune regulation

Moreover, it was observed that the intracellular Fe 2+ level increased in TBH-treated ARPE-19 cells but that there was no significant change in Fe 2+ after pretreatment with FER-1 or deferoxamine (DFO) ( In neovascular AMD, RPE cells generate vascular endothelial growth factor (VEGF) when they are under hypoxia or oxidative stress ( 2+

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doi: 10.1016/j.rmed.2008.11.009

42 (Springer, 2009)

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