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however, the sample was very small and administration timing was not closely monitored to achieve optimal pharmacokinetics of NAC [107]

TABLE 3 Bioactive flavor compounds in baijiu and their beneficial effects

Potential interactions with insulin and other antidiabetic agents should be considered

Fumarate, an allosteric activator, can largely increase ME2 activity by lowering K 0.5,malate and K m,NAD, thus enhancing the affinity of ME2 for its substrates (Fig