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In an experimental study with the use of human thyroid follicles isolated from normal paranodular tissue, it was observed that a high iodide dose (10 3 M) caused marked inhibition of radioiodine accumulation and organification process, as well as it induced necrosis of thyrocytes and ultrastructural lesions such as apical blebbing, cytoplasmic fragments desquamation, endoplasmic reticulum vesiculation, and accumulation of lipofuscin in secondary lysosomes [174]