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[DOI] [PMC free article] [PubMed] [Google Scholar] 23.Lee B., Moon K.M., Kim C.Y

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Quantitative analyses reveal that both cytokine concentration and temporal expression patterns significantly influence subsequent neurodegenerative progression, with chronic low-level inflammation potentially exerting more detrimental effects than acute inflammatory responses due to the cumulative impact of sustained neuronal exposure to inflammatory mediators (36, 37)

Thus, natural compensatory mechanisms may develop to a lesser extent in MPTP-treated monkeys