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Given the broad scope and varying definitions of rare diseases worldwide, our analysis focused on the top ten rare diseases with the highest levels of research and development (R&D) activity 14

DeFoor MT, Dekker TJ

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While some human studies report a high prevalence of zinc deficiency in patients with thyroid dysfunction and a positive correlation between serum zinc and thyroid autoantibody titers in patients with autoimmune thyroiditis ( Iron and AITD Iron is an essential cofactor for TPO, fulfilling a dual role in thyroid hormone synthesis: it facilitates crucial redox reactions and maintains the enzymes catalytic activity ( Table 1 ) has established that nutritional iron deficiency impairs thyroid metabolism, consistently leading to reduced plasma T4 and T3 levels, diminished peripheral T4-to-T3 conversion, and elevated TSH ( Copper and AITD Copper (Cu), an important immune-modulating trace element, exists in plasma primarily in the form of ceruloplasmin-bound copper, accounting for over 90% of its total plasma concentration