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P139 Malinovska Nikolovska L

Abstract Cystinotic patients have been shown to excrete in their urine high levels of pyroglutamate, an intermediate metabolite of the adenosine triphosphate (ATP)dependent -glutamyl cycle, which is responsible for glutathione (GSH) synthesis

This route benefits individuals with chronic inflammation, weak digestion, or any condition affecting nutrient uptake

Am J Pathol 159 : 18151826

The clinical relevance of TMAO was emphasized by a positive correlation between plasma levels of TMAO and major cardiovascular events (death, myocardial infarction, or stroke) in 4000 patients 3