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Effects were seen at extremely low concentrations (10 -12 to 10 -9 M), but higher concentrations actually inhibited growth demonstrating a precise dose-response relationship

Pickart L, Freedman JH, Loker WJ, Peisach J, Perkins CM, Stenkamp RE, Weinstein B (1980) Growth-modulating plasma tripeptide may function by facilitating copper uptake into cells

Theres insufficient safety data on GHK-Cu in pregnancy or breastfeeding

Dutasteride is stronger but has a different safety profile and is often used off-label

The methodology combining ex vivo follicle organ culture with multiple in vitro molecular assays is considered a strong experimental design for hair growth research

Together, these findings suggest that G/D-CuP promotes macrophage polarization toward the M2 phenotype, thereby reducing inflammation, enhancing antioxidant capacity, and ultimately accelerating effective wound healing