glutathione pathway metabolites Metabolism - an overview GLUTATHIONE SYNTHESIS - PMC

The physiological relevance of the kinetic uncoupling is that it allows the formation of stable complexes, for example, with ironsulfur clusters or disulfide-bonded interaction partners

This adjustment to OS would result in low levels of mitochondrial ROS, increased mitochondrial respiration, and resistance to chemotherapy (Oliva et al., 2011)

The lipid peroxidation is a free radical-driven reaction that primarily affects polyunsaturated fatty acids (PUFAs) in cell membranes, the product of which gradually increases during the ferroptotic cell death, from the initial lipid hydroperoxides (LOOHs) to the later production of malondialdehyde (MDA) and 4-hydroxynenoal (Kagan et al., 2017)

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It was also found that 968 was capable of reversing adriamycin resistance in MCF-7/ADR, a drug-resistant cell line of BC, in a time- and drug-concentration-dependent manner [145]

The obtained final models were examined in VMD, PyMOL, and SPDBV by visual inspection searching for putative unsolved clashes 74,75,102,107