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The production of gamma-glutamylcysteine is the rate limiting step in the production of GSH (Maher 2006), due to the limited availability of cysteine (the oxidized form of the amino acid cystine)

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Furthermore, it is associated with an increased risk of cardiovascular disease, which is the leading cause of death among affected patients (Rovin et al., 2024) and other complications include anemia, bone disease, and electrolyte imbalances

Role in immune defense and cellular protection: Glutathione plays an important role in normal immune function and is being studied for its involvement in the body's response to viral infections and cellular protective mechanisms

The hyperactivation of the gap junction protein connexin 43 (Cx43) increases the expression of p53, p16INK4a, and NF-B, which are positively correlated with aging

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