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In a 48-week Phase 2 trial published in the New England Journal of Medicine (Sanyal and colleagues, NCT04771273), 293 adults with biopsy-confirmed MASH and fibrosis stage F1 through F3 were randomized 1:1:1:1 to once-weekly subcutaneous survodutide at 2.4, 4.8, or 6.0 mg or placebo, again using a 24-week rapid escalation followed by a 24-week maintenance phase

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Non-biodegradable precious metal nanozymes (such as Pt, Au) may accumulate for a long time in certain organs, and their potential chronic toxicity remains unclear