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Second, the MCD model does not robustly activate de novo lipogenesis, and GADD45 may influence lipid accumulation via alternative pathways, such as fatty acid uptake or oxidation, which were not functionally explored

It typically peaks during dose escalation and resolves within 1-2 weeks at each new dose level

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26 Serum B 12 , homocysteine, and methylmalonic acid (MMA) levels (box 2) are unreliable predictors of B 12 responsive neuropathy (neurological disorders that respond to B 12 supplementation)