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The culture medium, containing the respective compounds or DMSO vehicle, was replaced every 2 days

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IGF-1 modulates synaptic plasticity primarily by regulating ion channels (Ca 2+ -binding proteins), neurotransmitter secretion, and neuronal arborization

Although they also provide structural support to the synovial tissue that lines the joint capsule, a key role of synovial fibroblasts is the provision of nutrients to the avascularised cartilage and lubrication to the joints by the release of hyaluronan and lubricin into the synovial fluid allowing the movements of the joints ( In summary, all the actions discussed above can be grouped into the structural side of fibroblasts