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Convenient dosing: A single weekly subcutaneous dose is easier to keep up than daily regimens [3]

Although, endogenous melatonin production is closely related with the onset and offset of sleep, few associations have been found between melatonin production and sleep stages (95), and sleep deprivation does not abolish the melatonin rhythm

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For HGF expression, 5% of FBS (Sigma) was supplemented to the culture media

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