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However, when excess free Fe 2+ is present in the cell, ferritin is recruited and solubilized by specific cargo receptor recognition, and the released excess Fe 2+ in turn increases the formation of hydroxyl radicals through the Fenton reaction, inducing reactive oxygen species (ROS) production and increased susceptibility to cellular ferroptosis ( FIGURE 1 Lipid peroxidation is an important factor driving ferroptosis

The localization of MRP1 at the luminal membrane of these cells indicates that the transporter is involved in the further transfer of MeHg into the fetal bloodstream

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In the process of neutralizing free radicals, antioxidants themselves become oxidized

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