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While this perfect score suggests a high risk of overfitting, it also provides strong evidence that the metabolic flux profiles of EP and LP cultures are highly separable

doi: 10.1016/s0928-4257(01)00036-5

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Of these two, itraconazole has most promise as a pharmaceutical invention targeting NPC1, since it is already included in several clinical trials as an anti-cancer drug due to its ability to inhibit hedgehog pathway as well as due to its various anticancer activities including its ability to target multidrug resistance via ABC transporters [120]