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J Med Assoc Thai 2014;97 Suppl 11:S31-S40

Numerous studies have verified that eNOS activation and NO generation may prevent atherosclerosis and reduce the senescence of endothelial cells (Liang et al., 2021

This evidence suggests that alterations in itaconate and cysteine-S-sulfate levels could serve as potential biomarkers for the diagnosis and progression of PD and provide insights for the development of new therapeutic strategies aimed at modulating inflammation and excitotoxicity in the context of PD

Moreover, in a xenograft mammary 4T1 tumor model, it has been demonstrated that the concurrent administration of BAPN and the enzyme-responsive drug (NQO1-SN38), designed to target breast tumors with the topoisomerase I inhibitor SN38, results in a cooperative reduction in tumor growth [100]