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By the time chyme passes from the ileum into the large intestine, it is essentially indigestible food residue (mainly plant fibers like cellulose), some water, and millions of bacteria

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Additionally, to the best of our knowledge, high-quality, longitudinal clinical studies specifically targeting perimenopausal populations are lacking

Notably, although gcs-1 induction is impaired in CSN-deficient animals (Figures 3A,B, 2B upper panel), the high basal gcs-1 expression and increased expression of other phase 2 detoxification genes, e.g., gst-7 (Figure 2B lower panel, see Additional file 2: Figure S5), is sufficient to confer increased oxidative stress resistance (Figures 2C and 3C) [17]

10.3390/cells13141175 54 KhanS.HussainA.AttarF.BloukhS

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