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In contrast, when neurospheres were co-cultured with HT-22 cells pretreated with high glucose, the differentiated immature neurons showed shortened neurites with reduced MAP2-positive areas, although the number of precursor cells remained unchanged

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These paradigm-shifting approaches demonstrate how precision-engineered ICD induction can overcome tumor immunosuppression, offering blueprint frameworks for next-generation immuno-oncology therapeutics (Figure 5)