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Furthermore, in vitro studies that aim to simulate oral drug exposure should verify whether the applied flavonoid concentrations are achievable through in vivo metabolism following oral intake

M1 macrophages are involved in the immune response and immune monitoring through antigen presentation and the release of pro-inflammatory cytokines like IL-1 and TNF- (87)

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This initial work set the stage for subsequent studies to explore redox-sensitive targets in skeletal muscle

doi:10.3109/00498259409043238 Furfaro AL, Nitti M, Marengo B, Domenicotti C, Cottalasso D, Marinari UM, Pronzato MA, Traverso N (2012) Impaired synthesis contributes to diabetes-induced decrease in liver glutathione