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Discussion Progressive intracellular accumulation of SCMAS, starting within the lysosomes, is a hallmark of CLN3 Batten disease [42]

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Some of the resistance is revealed in comments written by Haurowitz in 1959: 'It is very difficult for a chemist to accept this hypothesis because it cannot be translated into the language of chemistry.' Overall those with a more biological orientation were more favourable to the new theory than those of a chemical disposition

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