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Fusion partners address these problems through several mechanisms (Esposito & Chatterjee, 2006): Folding nucleation: Large, fast-folding fusion partners (MBP, NusA) fold first and create a local environment that promotes downstream folding of the passenger protein

Enhanced nuclear translocation of TFEB boosts the expression of lysosomal proteins and superoxide dismutase (SOD), ultimately diminishing ROS levels and suppressing ferroptosis, thus exerting a protective effect (254)

These processes are controlled by SAM and SAH, which depend on vitamins B6, B9, and B12

& Rosenthal, N

Table 1 Annotations features for glutathione transferase of Spirometra mansoni

Alternatively, GSH is efficiently synthesized by utilizing intracellular cysteine (L-cysteine), glycine and glutamate, with the assistance of specific enzymes (37,38)