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Its circulating half-life is relatively short

For comparisons among three or more independent groups, one-way analysis of variance (ANOVA) followed by Tukeys multiple comparisons test was applied when variances were equal, whereas Welchs ANOVA with Dunnetts T3 post-hoc test was used when variances were unequal

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For example, ganoderic acid A activates the NRF2/SLC7A11/GPX4 axis (108), whereas saponins derived from Astragalus membranaceus act on the NOX4/NRF2 pathway to restore iron balance (109)

Levine AJ, Hu W, Feng Z

The possible functional importance of such binding to other serum/plasma molecules is not known, but the removal of ferritin from the circulation through the receptor-mediated endocytosis of -2-macroglobulin may be a possibility