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doi: 10.1016/j.pnpbp.2017.11.020 143 VandewalleJLuypaertADe BosscherKLibertC

A membrane-free gut-on-chip study revealed that candidalysin disrupts tight junction proteins (ZO-1, occludin) to induce leaky gut, and further induces intestinal epithelial cells (IECs) apoptosis and necroptosis, thereby exacerbating barrier breakdown 111

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A recent in silico study have further identified the molecular targets of apigenin involved in inflammatory pathways, including IKK, the NF-B p50p65 heterodimer, p38 MAPK, and COX-2 (86)

Worth noting, there is no direct proof regarding the clinical effects of ferroptosis-specific inhibitors or activators in eye diseases

But that may come to an end when all the serotonin from the neurons is in the synapses