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Despite the fact that in the HFD + NAC group there was a significant decrease in the CAS-9 expression compared to the HFD group (21% p = 0.0379, respectively), its level was still significantly higher compared to the control group (26% p = 0.0492, respectively) (Fig

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For example, the accepted view is that general control nonderepressible 2 (GCN2) senses decreased tRNA charging after a reduction in hepatic amino acids and initiates the ISR through increased phosphorylation of eukaryotic initiation factor 2 alpha (eIF2) 9,10,11,12,13,14,15,16