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Although pharmacodynamic synergy has not been conclusively demonstrated, convergent evidence from preclinical models supports a systems-level paradigm in which ginsenosides exert antidepressant-like effects through coordinated, multilayer modulation rather than isolated single-target actions

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For determination of glutathione content of rat liver cytosol, the increase of fluorescence due to GSH conjugate was converted to corresponding concentration of glutathione in the reaction mixture since 1.0 fluorescence unit recorded on the chart corresponded to 0.1 M concentration of GSH conjugate

Researchers used a combination of oral (1000 mg/day) and intramuscular treatment [74]

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