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Biochemical assessment of carboxylesterase enzyme activity CXEs activity was determined using -naphthyl acetate as a substrate

Rich P, Gooderham M, Bachelez H, Goncalves J, Day RM, Chen R, Crowley J (2016) Apremilast, an oral phosphodiesterase 4 inhibitor, in patients with difficult-to-treat nail and scalp psoriasis: results of 2 phase III randomized, controlled trials (ESTEEM 1 and ESTEEM 2)

doi: 10.3760/cma.j.issn.2095-4352.2019.02.028 70 SongDLaiLRanZ

doi: 10.1093/pcp/pcs100 54 GadjevI.StoneJ

GhK-cu is a small peptide associated with tissue repair and cell signaling that can impact reproduction

However, they also state that there is little evidence to support this recommendation