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Pharmacokinetic characterization in porcine models demonstrated an intravenous half-life of approximately 3 minutes, with rapid degradation via sequential amino-terminal amino acid removal and confirmed oral bioavailability

Ab68 antibodies (Abs) demonstrated potent NAD + and NMN boosting activity 36 , are incapable of traversing the BBB, and their superior target specificity suggests a significantly safer profile than small molecule CD38 inhibitors