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Similar mutation spectra have been obtained TABLE 3-14 Mutation Spectra Indicative of Environmental Exposures and DNA Damage TABLE 3-15 VHL Mutations in Sporadic Renal Cell Carcinomas from cells and animals treated with alkylating agents, such as nitrosamines found in tobacco smoke and potent human and animal renal carcinogens

Renal conditions were reported in many patients and were excluded before conducting our study to reduce confounding in this small cohort

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