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Vargas R, Martinez-Martinez N, Lizano-Barrantes C et al (2025) Advancing through the blood-brain barrier: mechanisms, challenges and drug delivery strategies: review paper

Although experimental structural information on DIDO SPOC is lacking, AlphaFold2 structure prediction 26,27 shows that the conserved residues cluster in patches on the domain surface similar to PHF3 SPOC (Fig