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The skin barrier is designed to protect, which means large antioxidant molecules like glutathione may not penetrate deeply enough in cream form to create dramatic changes in pigmentation

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This phenomenon may be related to the role of DCs in maintaining redox homeostasis in the DC-T cell interaction microenvironment through glutathione export[73, 76]

In order to rescue the expression of chimeras M1, M3, M4 and M7, and increase the expression of M2, we tested the effectiveness of the chemical chaperone 4-phenyl butyric acid (4-PBA) 37 , at 5 mM for 24 h in comparison with MRP1 wild type (WT) expression in the same conditions