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B 8 , 699712 (2018)

Food intake and body weight were not significantly affected by proxidant treatment at any point

This leads to their clustering and activation, which also induces a conformational change [42,43]

Another study by Wan et al., conducted on healthy volunteers, revealed that AUC (0168 h) and AUC (0-) values of gefitinib were higher by 33% and 37%, respectively, in individuals with CA + AA genotypes than in patients with the CC genotype ( p G) of FOXO3 and found a significant association with hepatotoxicity, where the AA carriers had a higher tendency to develop hepatotoxicity than those with GG genotype ( p = 0.018) [96]