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Although the double and triple combinations at reduced doses did not decrease MYCN levels after 24 hours, they potently diminished MYCN protein levels in the IMR-5/75 cell line

TRPM7 conditional knockout mice alleviated neuronal damage and pyroptosis and reversed PILO-treated neuronal hyperexcitability We successfully generated TRPM7 conditional knockout (CKO) mice by crossing TRPM7 f/f mice with Cre transgenic mice (Supplemental Fig

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Any interpretation beyond laboratory research is speculative

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Interestingly, despite sharing mechanisms of induction and expression, tetanus-induced LTP was input-specific implying the need for presynaptic activation for the induction while LTP induced by AP trains was clearly independent of presynaptic activity at test synapses