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Recent research found that trained macrophage acquired memory-like characteristics in response to antigen exposure can be targeted to SSc treatment

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doi: 10.1016/j.ejmech.2022.114884 162 YuMWuYLiQHongWYangYHuXet al

For instance, reduced mtDNA copy number in subcutaneous adipose tissue is a well-documented feature of the lipoatrophy caused by older NRTIs like stavudine (d4T) and zidovudine (AZT), as mtDNA depletion impairs adipocyte differentiation and triglyceride storage

Susmitha, S., Ranganayaki, P., Vidyamol, K., and Vijayaraghavan, R., Int

[45] It has been suggested that mutations that increase iron absorption, such as the ones responsible for hemochromatosis (see below), were selected for during Neolithic times as they provided a selective advantage against iron-deficiency anemia