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For example, a previous study on PD brains showed an increase in lipid peroxidation products, such as 4-hydroxinonenal, and in protein crosslinking and fragmentation [51], suggesting that oxidative stress may affect other brain regions apart from the SN

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Protein carbonyls are elevated in brains that have been exposed to free radical insults resulting from ionizing radiation that splits water into reactive OH radicals, metabolism of certain chemicals/pharmaceuticals, e.g., rotenone, that leads to inhibition of complex I of the mitochondrial electron transport chain, aging, and certain neurodegenerative disorders such as Parkinson disease, Huntington disease, amyotrophic lateral sclerosis, and AD (among other disorders) (3337)