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These pathway-level predictions were experimentally validated, as PYC significantly suppressed IL-6 and IL-1 expression in lipopolysaccharide-induced BV2 microglial cells, supporting its multi-component, multi-target mode of action ( Although in vitro studies have provided substantial evidence of anti-inflammatory activity, corresponding evaluations using in vivo models remain limited

174 One reason for inconsistent results may be the lack of a standardized protocol, including dose of pulses and duration of treatment

PMID: 39048638

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These lamellae are predominantly composed of radially and circumferentially oriented type I collagen fibers (Mohd Isa et al., 2022)

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