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Recent human studies show that even short durations of moderate-intensity exercise (e.g., 15 minutes at ~55% heart rate reserve) can mobilize cytotoxic NK cells into the bloodstream ( dim and CD57 + NK cells, which have been observed to increase after moderate exercise in pediatric hematopoietic stem cell transplant recipients ( + ) remain elevated for more than an hour post-exercise, reinforcing the hypothesis that physical activity may contribute to immune-mediated senolysis ( These findings further support the concept that moderate-intensity exercise not only enhances immune surveillance of NK cells in the context of tumor defense but may also contribute to the clearance of senescent cells, thus playing a role in aging and tissue homeostasis

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IFN- is one of the primary cytokines released by effector CD8 + T cells [179, 180]

Another novel AC5 inhibitor, C90, inhibits cAMP production to FSK by 42% in WT but not in AC5KO, suggesting its selective AC5 inhibitory effect

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