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Azurophilic granule proteins such as NE and MPO have to translocate to the nucleus to decondensate chromatin which then diffuses into the cytoplasm where additional antimicrobial and cytoplasmic proteins are attached to form early-stage NETs

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More strictly to human studies, in 16 breast cancer patients treated for 10 days, bromelain could reduce CD44 expression (similar to above), while augmenting CD11a and CD62L expression (125)

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