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218 LTB4 activates the BLT1 receptor on VSMC and induces VSMC activation and proliferation through an IKK-NF B-dependent pathway, which is important in early atherosclerotic formation

Cartilage 13 , 1572S1585S (2021)

Sikiric P, Seiwerth S, Rucman R, Drmic D, Stupnisek M, Kokot A, Sever M, Zoricic I, Zoricic Z, Batelja L, Ziger T, Luetic K, Vlainic J, Rasic Z, Bencic ML

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that bone loss was most pronounced in weight-bearing skeletal sites, with no significant changes in non-weight-bearing areas such as the radius, suggests that mechanical unloading may be a key driver of bone resorption rather than a direct pharmacologic effect of GLP-1 receptor activation

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